ECCMID 2018 | Events
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Highlights and data from ECCMID 2018

April 21–24, 2018    |    Madrid, Spain    |    Booth 12

Experience the technology through our interactive demonstration and learn about the reporting features of Accelerate Pheno™ System. See the instrument and user interface in action and schedule a one-on-one meeting with key team members.


28th ECCMID (European Congress of Clinical Microbiology and Infectious Diseases).
Dates: April 21-24, 2018
Location: IFEMA – Feria de Madrid, Madrid, Spain
Booth: 12
Social Media: #ECCMID2018
Event Website: www.eccmid.org


Learn more about the Accelerate Pheno™ system

Best Practices in Management of Hospitalized Patients with Bacteremia: Integrating Diagnostics, Sepsis Protocols and Antimicrobial Stewardship
Where:

Hall L

When:

Monday, 23 April
09:00 – 11:00


CHAIR: Prof. Stefania Stefani University of Catania, Catania - Italy
CO-CHAIR: Prof. Djillali Annane AP-HP Hôpital Raymond Poincaré, Garches - France
ESCMID CHAIR: Prof. Jordi Rello Vall d’Hebron Barcelona Campus Hospital, Barcelona - Spain

9:00 - 9:05
Presentation of Symposium Program and Speakers

Presented by: Prof. Stefania Stefani, Prof. Djillali Annane
Chair & Co-Chair

9:05 - 9:25
Challenges of Antibiotic Stewardship in the Critically Ill

Presented by: Prof. Jan De Waele
Ghent University, Ghent - Belgium

9:25 - 9:45
Individualized Antibiotic Therapy in Critical Care

Presented by: Prof. Fabio Taccone
ULB – Hôpital Erasme, Brussels - Belgium

9:45 - 9:55
Q&A

9:55 - 10:20
Case Studies in Bacteremia, Sepsis and Septic Shock

Presented by: Dr. Claire Thomas
Hampshire Hospitals NHS Foundation Trust, Basingstoke – UK

10:20 - 10:30
Q&A

10:30 - 10:50
Critical Need to Develop Susceptibility Testing Capacity in Clinical Laboratories

Presented by: Dr. Romney Humphries
Accelerate Diagnostics, Tucson - USA

10:50 - 11:00
Final Q&A

Assessing the clinical impact of rapid pathogen identification (ID) and antimicrobial susceptibility testing (AST) provided by the Accelerate Pheno™ system at Hampshire Hospitals NHS Foundation Trust (HHFT)
Author(s): Stephen Peter Kidd, Stephen Poole, Nathan Moore, Christina Petridou, Kordo Saeed, Claire Thomas, Nick Cortes, Nicki Hutchinson
From the data
“Projection of ~5,500 doses saved/annum of Tazocin and ~2,500 doses saved/annum of total antibiotic usage.”
“1,278 patient exposure days to multidrug resistant organisms saved.”
“Clinical actions a mean of 1.57 days earlier compared to SoC.”
Accelerating time-to-pathogen-adapted antibiotic treatment through subculture-independent phenotypic AST in patients suffering from sepsis
Author(s): Matthias Karrasch, Marco Bender, Jennifer Geraci, Jürgen Rödel, Frank Martin Brunkhorst, Bettina Löffler
From the data
“ID Performance for 89 evaluable organisms – sensitivity: 92.2%, specificity: 99.8%.”
“Average time to result reduction (GP+GN): ID reduction of 14,42 h and AST reduction of 25,59 h.”
“ID/AST results would have led to a reduced time-to-treatment, if reported. System could thus serve as an innovative antibiotic stewardship (ABS) diagnostic tool.”
Comparative evaluation of Accelerate Pheno™ system and VITEK® 2 systems for rapid antibiotic susceptibility testing of pathogens in positive blood cultures
Author(s): Giulia De Angelis, Teresa Spanu, Tiziana D’Inzeo, Giulia Menchinelli, Patrizia Posteraro, Gabriella Parisi, Maurizio Sanguinetti, Brunella Posteraro
From the data
“The overall categorical agreement between Accelerate Pheno™ system and BMD was 92.7% (467/504) for Gram-negative organisms and 99.0% (95/96) for Gram-positive organisms.”
“Importantly, in contrast with the VITEK® 2 system, no false-susceptible results occurred with two colistin-resistant organism-growing PBCs tested using the Accelerate Pheno™ system.”
Evaluation of Accelerate Pheno™ system, a rapid identification and antibiotic susceptibility testing (AST) system, in the Hospital Universatario de la Princesa
Author(s): Nelly Daniela Zurita Cruz, Laura Llorca, Sara Gómez de Frutos, Belén Fernández-Caso, Tamara Soler Maniega, María Carmen De las Cuevas, Laura Cardeñoso
From the data
“ID by the Accelerate Pheno™ system was successful for 92% (n=69) of blood cultures.”
“The Accelerate Pheno™ system was able to correctly identify the microorganisms isolated in 80% of the polymicrobial bacteremias.”
“The Accelerate Pheno™ system identified pathogens directly from positive BC, including polymicrobial bacteremia, in 1.5 h and offered AST in less than 8 h.”
  Association between identification and antibiotics susceptibility testing with Accelerate Pheno™ system and the antimicrobial management of patients with severe sepsis from the Hospital Universitario de La Princesa
Author(s): Nelly Daniela Zurita Cruz, Laura Llorca, Sara Gómez de Frutos, Tamara Soler Maniega, María Carmen De las Cuevas, Laura Cardeñoso
From the data
“Our results show that the Accelerate Pheno™ system allows for antibiotic de-escalation and adequate treatment of patients with severe BSI and sepsis at least 28 h earlier than conventional phenotypic AST.”
“ID averaged 8:49h by optimized MALDI-TOF lab methods vs. 1:21h by the Accelerate Pheno Test™ BC kit. AST averaged 38:23h by current lab AST algorithms vs. <7h by the Accelerate Pheno Test™ BC kit.”
Evaluation of the Accelerate Pheno™ system for the diagnosis of bloodstream infections (BSIs) in bacterial bloodstream infection
Author(s): Giuseppe Giuliani, Marina Re, Luisa Re, Cristina Rescaldani, Lora Manolia, Roberto Ottaviano
From the data
“On a total of 48 BSIs, of which 29 were Gram-negative, 18 were Gram-positive, and 1 was polymicrobial, the Accelerate Pheno™ system provided 95.8% correct identification.”
“Our study demonstrated that the Accelerate Pheno™ system identifies organisms 16.5h before cultured-based identification.”
“The Accelerate Pheno™ system’s AST results were available 39h earlier compared to conventional culture-based AST.”
Comparison of Accelerate (AXDX) BC Pheno™ system test results from Gram-negative bacilli (GNB) parallel-seeded to FA-plus blood culture bottles (BCB) incubated in bioMerieux BacT/Alert-3D and VirtuO systems
Author(s): Barbara M. Willey, Anthony Oppedisano, Ebuka Osuji, Yaroslav Sokolskyy, Mustafa Al-Ani, Herman Ng, Aimee Paterson, Pauline Lo, Tony Mazzulli, Susan Poutanen
From the data
“As with previous evaluations, using the Accelerate Pheno Test™ BC kit, ID and AST, for most organisms and agents was associated with a significant reduction in ID and AST TAT.”
Diagnostic accuracy of Accelerate Pheno™ system on antimicrobial susceptibility test in comparison to broth microdilution method
Author(s): Tianyan Song, Tor Monsen
From the data
“Isolates tested in this study include not only blood isolates but also isolates from other infection sites e.g. wounds.”

 

Accelerate Pheno™ system test: the experience of the microbiology and virology laboratory – San Camillo Hospital – Rome
Author(s): Paola Maria Placanica, Gabriella Parisi, Bruno Mariani, Rosa Maria Oliverio, Mariarosa Gaudio, Daniela Orazi
From the data
“For Gram-positives, the The Accelerate Pheno™ system’s AST results agreed perfectly with the reference tests, and for Gram-negatives, the overall agreement was 95.2%.”
“The Accelerate Pheno™ system represents an appropriate solution for determining correct and focused therapy for septic patients by providing complete, clinically relevant and rapid ID and AST results with MIC values. ”
“For bloodstream infections, a rapid switch from empiric to optimal antibiotic therapy plays an important role in the reduction of mortality, length of stay and the decrease of antimicrobial resistance.”
Case Studies in Bactereamia, Sepsis, and Septic shock
Presented by: Dr. Claire Thomas
Case Studies in Bactereamia, Sepsis, and Septic shock (Full Video)
Presented by: Dr. Claire Thomas
The Challenge of Antimicrobial Stewardship in the Critically Ill
Presented by: Prof. Jan J. De Waele
Individualized Antibiotic Therapy in Critical Care
Presented by: Prof. Fabio Taccone

Recent Publications

Sep 19, 2018

Impact of Accelerate Pheno™ system Rapid Blood Culture Detection System on Laboratory and Clinical Outcomes in Bacteremic Patients
IDWeek 2018

Aug 30, 2018

Performance and diagnostic accuracy of Accelerate Pheno™ system on clinical blood cultures in diagnosis of bacteremia
Swiss Society for Microbiology

Jun 11, 2018

Using Implementation Science for Fast Phenotypic Diagnostic for Bloodstream Infections and Antimicrobial Stewardship
AHA Leadership Summit

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